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Karel Pacak Selected Research

Adrenergic Receptors (Adrenergic Receptor)

2/2022Differences in clinical presentation and management between pre- and postsurgical diagnoses of urinary bladder paraganglioma: is there clinical relevance? A systematic review.
1/2020Pathophysiology and Acute Management of Tachyarrhythmias in Pheochromocytoma: JACC Review Topic of the Week.
1/2019WHY TAKE THE RISK? WE ONLY LIVE ONCE: THE DANGERS ASSOCIATED WITH NEGLECTING A PRE-OPERATIVE ALPHA ADRENOCEPTOR BLOCKADE IN PHEOCHROMOCYTOMA PATIENTS.
1/2019A NECESSITY, NOT A SECOND THOUGHT: PRE-OPERATIVE ALPHA-ADRENOCEPTOR BLOCKADE IN PHEOCHROMOCYTOMA PATIENTS.
1/2016Are patients with hormonally functional phaeochromocytoma and paraganglioma initially receiving a proper adrenoceptor blockade? A retrospective cohort study.
6/2010Exercise-induced nausea and vomiting: another sign and symptom of pheochromocytoma and paraganglioma.
1/2010Monoamine oxidase A-mediated enhanced catabolism of norepinephrine contributes to adverse remodeling and pump failure in hearts with pressure overload.

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Karel Pacak Research Topics

Disease

227Neoplasms (Cancer)
04/2024 - 01/2002
193Pheochromocytoma
04/2024 - 03/2002
172Paraganglioma (Paragangliomas)
04/2024 - 03/2002
44Neoplasm Metastasis (Metastasis)
12/2023 - 08/2006
29Hypoxia (Hypoxemia)
12/2023 - 09/2012
27Neuroendocrine Tumors (Neuroendocrine Tumor)
04/2024 - 07/2003
21Hypertension (High Blood Pressure)
04/2024 - 09/2002
14Multiple Endocrine Neoplasia Type 2a (MEN 2)
06/2017 - 06/2005
13von Hippel-Lindau Disease (von Hippel Lindau Disease)
10/2022 - 02/2005
9Carcinogenesis
01/2019 - 06/2005
8Tachycardia (Tachyarrhythmias)
12/2023 - 03/2008
8Polycythemia (Erythrocytosis)
10/2023 - 03/2013
8Obesity
01/2019 - 11/2006
8Neurofibromatosis 1 (Neurofibromatosis Type I)
06/2017 - 06/2005
6Disease Progression
11/2023 - 01/2013
6Renal Cell Carcinoma (Grawitz Tumor)
01/2023 - 03/2012
6Heart Failure
12/2022 - 11/2006
5Somatostatinoma
05/2024 - 03/2013
5Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor)
01/2023 - 01/2008
5Cardiomyopathies (Cardiomyopathy)
07/2019 - 06/2011
4Hypotension (Low Blood Pressure)
12/2023 - 07/2003
4Hypertensive Crisis
12/2023 - 01/2004
4Hemangioblastoma
12/2021 - 01/2017
4Hyperplasia
07/2019 - 05/2006
4Cushing Syndrome
08/2018 - 05/2004
3Pain (Aches)
04/2024 - 01/2020
3Glioblastoma (Glioblastoma Multiforme)
01/2024 - 08/2017
3Adrenal incidentaloma
01/2024 - 08/2005
3Neuroblastoma
08/2023 - 03/2005

Drug/Important Bio-Agent (IBA)

98CatecholaminesIBA
04/2024 - 03/2002
84Succinate Dehydrogenase (Fumarate Reductase)IBA
04/2024 - 06/2005
29Norepinephrine (Noradrenaline)FDA LinkGeneric
12/2020 - 02/2002
25Proteins (Proteins, Gene)FDA Link
09/2023 - 10/2005
23Biomarkers (Surrogate Marker)IBA
10/2023 - 12/2002
21Epinephrine (Adrenaline)FDA LinkGeneric
12/2023 - 06/2003
21EnzymesIBA
09/2023 - 08/2006
18MetanephrineIBA
01/2023 - 05/2002
17Radioisotopes (Radionuclides)IBA
11/2023 - 05/2004
16NormetanephrineIBA
01/2023 - 05/2002
16Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link
01/2021 - 08/2004
15RadiopharmaceuticalsIBA
01/2021 - 08/2004
13Succinic Acid (Succinate)IBA
12/2023 - 01/2013
133-methoxytyramine (methoxytyramine)IBA
01/2023 - 04/2005
13Dopamine (Intropin)FDA LinkGeneric
04/2019 - 07/2003
12Somatostatin Receptors (Somatostatin Receptor)IBA
04/2024 - 03/2004
12gallium Ga 68 dotatateIBA
10/2022 - 02/2016
12fluorodopa F 18IBA
03/2020 - 10/2007
11LigandsIBA
01/2024 - 03/2005
11Hormones (Hormone)IBA
01/2022 - 08/2003
11Somatostatin (Somatotropin Release-Inhibiting Factor)IBA
01/2021 - 08/2008
113-Iodobenzylguanidine (Iobenguane)IBA
01/2019 - 09/2003
10MannansIBA
01/2024 - 05/2019
8Phosphotransferases (Kinase)IBA
11/2022 - 06/2013
8Adrenergic Agents (Adrenergic Drugs)IBA
01/2022 - 06/2005
8ErythropoietinFDA Link
01/2021 - 06/2005
7DNA (Deoxyribonucleic Acid)IBA
05/2024 - 09/2002
7Adrenergic Receptors (Adrenergic Receptor)IBA
02/2022 - 01/2010
7Myc associated factor XIBA
01/2018 - 05/2012
7Messenger RNA (mRNA)IBA
11/2012 - 10/2005
7Norepinephrine Plasma Membrane Transport Proteins (Norepinephrine Transporter)IBA
11/2012 - 02/2003
6lutetium Lu 177 dotatateIBA
04/2024 - 06/2019
6Toll-Like Receptors (Toll-Like Receptor)IBA
01/2024 - 05/2019
64-carboxyphenylglyoxalIBA
01/2023 - 01/2020
6Tricarboxylic AcidsIBA
01/2022 - 08/2015
6Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
12/2021 - 08/2014
6Peptide Receptors (Peptide Receptor)IBA
01/2021 - 12/2016
6Adenosine Triphosphate (ATP)IBA
01/2019 - 01/2013
51,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acidIBA
01/2023 - 02/2016
5Transcription Factors (Transcription Factor)IBA
01/2023 - 08/2006
5Fumarate Hydratase (Fumarase)IBA
01/2023 - 03/2016
5Peptides (Polypeptides)IBA
01/2021 - 05/2007
5Carboxypeptidase H (Carboxypeptidase E)IBA
01/2020 - 11/2010
5Glucose (Dextrose)FDA LinkGeneric
11/2017 - 04/2012
4VaccinesIBA
01/2024 - 09/2020
4EverolimusFDA Link
01/2024 - 05/2015
4Temozolomide (Temodar)FDA LinkGeneric
11/2023 - 01/2017
4endothelial PAS domain-containing protein 1IBA
10/2023 - 05/2013
4RNA (Ribonucleic Acid)IBA
10/2022 - 12/2018
4Retinaldehyde (Retinal)IBA
12/2021 - 11/2017
4Reactive Oxygen Species (Oxygen Radicals)IBA
07/2021 - 01/2010
4IronIBA
01/2021 - 03/2011
4Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA
01/2021 - 06/2013
4Oxygen (Dioxygen)IBA
01/2020 - 03/2013
4Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA
04/2019 - 12/2008
4FumaratesIBA
01/2019 - 01/2014
4Prolyl Hydroxylases (Prolyl Hydroxylase)IBA
01/2018 - 01/2010
4ParaffinIBA
01/2017 - 03/2002
4Dihydroxyphenylalanine (Dopa)IBA
02/2012 - 08/2004
4Adrenocorticotropic Hormone (ACTH)FDA Link
08/2005 - 03/2004
3LipidsIBA
03/2024 - 01/2020
3AlpelisibIBA
01/2024 - 11/2019
3Sunitinib (Sutent)FDA Link
11/2023 - 05/2015
3ProteomeIBA
09/2023 - 06/2019
3Hydrocortisone (Cortisol)FDA LinkGeneric
08/2023 - 06/2017

Therapy/Procedure

62Therapeutics
04/2024 - 09/2002
14Precision Medicine
01/2024 - 11/2016
12Immunotherapy
02/2024 - 05/2019
11Drug Therapy (Chemotherapy)
01/2024 - 08/2008
8Adrenalectomy
01/2020 - 02/2003
7Radiotherapy
04/2024 - 12/2013